D21S418E IDENTIFIES A CAMP-REGULATED GENE LOCATED ON CHROMOSOME 21Q22.3 THAT IS EXPRESSED IN PLACENTAL SYNCYTIOTROPHOBLAST AND CHORIOCARCINOMA CELLS

被引：14
作者：
KIDO, S
SAKURAGI, N
BRONNER, MP
SAYEGH, R
BERGER, R
PATTERSON, D
STRAUSS, JF
机构：
[1] UNIV PENN,DEPT OBSTET & GYNECOL,778 CLIN RES BLDG,422 CURIE BLVD,PHILADELPHIA,PA 19104
[2] UNIV PENN,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104
[3] ELEANOR ROOSEVELT INST,DENVER,CO 80206
来源：
GENOMICS | 1993年 / 17卷 / 01期
关键词：
D O I：
10.1006/geno.1993.1317
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A partial cDNA (D21S418E) whose nucleotide sequence has no significant homologies with known mammalian DNA sequences was isolated from a human placental library. The cDNA hybridized with a 10-kb transcript present in term placenta. Messages of 10 and 7.5 kb were induced in BeWo and JEG-3 choriocarcinoma cells by treatment with 8-Br-cAMP. The mRNA was not detected in human brain, liver, lung, kidney, pancreas, heart, skeletal muscle, or myometrium. The D21S418E locus was assigned to a 3.5-Mb region of chromosome 21q22.3. © 1993 Academic Press. All rights reserved.
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页码：256 / 259
页数：4
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