THERAPEUTIC EFFECTIVENESS OF 2,3,2 TET, CYCLAM AND EDTA IN TOADS EXPOSED TO LETHAL DOSES OF NICKEL AND COBALT

被引：3

作者：

HILMY, AM ^{[1
]}

ELDOMIATY, NA ^{[1
]}

DAABEES, AY ^{[1
]}

AWADALLAH, AM ^{[1
]}

ABUTALEB, EM ^{[1
]}

机构：

[1] FAC EDUC ALEXANDRIA,DEPT BIOL,ALEXANDRIA,EGYPT

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1990年 / 95卷 / 01期

关键词：

D O I：

10.1016/0742-8413(90)90085-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. In the course of the present investigation, three chelating agents (2,3,2 tet, cyclam or EDTA) were tested for their therapeutic effect on nickel and cobalt poisoned toad. 2. 2. Our results showed that EDTA appears to be superior to the two other ligands, which have been proved to be chemical ligands for Ni and Co in vitro. 3. 3. EDTA was able to prevent disturbances in the activities of serum aspartate and alanine amino-transferases, alkaline phosphatase, total protein, urea, uric acid and blood glucose level. 4. 4. Our results suggest caution in the use of 2,3,2 tet or cyclam in human Ni and Co intoxication. © 1990.

引用

页码：79 / 83

页数：5

共 11 条

[1] REVISED ASSAY FOR SERUM PHENYL PHOSPHATASE-ACTIVITY USING 4-AMINO-ANTIPYRINE [J].