ENANTIOSELECTIVE BORANE REDUCTION OF KETONES CATALYZED BY A CHIRAL OXAZAPHOSPHOLIDINE BORANE COMPLEX

被引：17

作者：

BUONO, G

BRUNEL, JM

FAURE, B

PARDIGON, O

机构：

[1] Ecole Nationale Superieure de Syntheses de Procédés et d’Ingénierie Chimiques d’Aix-Marseille (E.N.S.S.P.I.C.A.M.), URA 1410 Réactivité catalyse, Faculté des Sciences et Techniques de St Jérôme, Universite Aix-Marseille III

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1993年 / 75卷 / 1-4期

关键词：

D O I：

10.1080/10426509308037360

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The borane complex of (2R,4S)-2-phenyl- 1,3,2-oxazaphospholidine 2 was readily synthetized. This complex can be used as catalyst in enantioselective reduction of ketones in toluene, with BH3:THF (or BH3:SMe2) as reducing agent. The catalytic reduction of iso-propyl methyl ketone yields (R)-3-methyl-2-butanol in 92% e.e. and 100% conversion. Reduction of different ketones under stoichiometric conditions gives the corresponding alcohols in e.e. = 99%.

引用

页码：43 / 46

页数：4

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