GENETIC-ANALYSIS OF AUTOIMMUNE TYPE-1 DIABETES-MELLITUS IN MICE

被引：502

作者：

TODD, JA

AITMAN, TJ

CORNALL, RJ

GHOSH, S

HALL, JRS

HEARNE, CM

KNIGHT, AM

LOVE, JM

MCALEER, MA

PRINS, JB

RODRIGUES, N

LATHROP, M

PRESSEY, A

DELARATO, NH

PETERSON, LB

WICKER, LS

机构：

[1] CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

[2] CTR ETUD POLYMORPHISME HUMAINE,F-75010 PARIS,FRANCE

[3] MERCK SHARP & DOHME LTD,DEPT CELLULAR & MOLEC PHARMACOL,RAHWAY,NJ 07065

[4] MERCK SHARP & DOHME LTD,AUTOIMMUNE DIS RES,RAHWAY,NJ 07065

来源：

NATURE | 1991年 / 351卷 / 6327期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/351542a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.

引用

页码：542 / 547

页数：6

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