SELECTION OF ANTIBIOTICS FOR TREATMENT AND PROPHYLAXIS OF STAPHYLOCOCCAL INFECTIONS IN CYSTIC-FIBROSIS PATIENTS

被引：4

作者：

BAUERNFEIND, A ^{[1
]}

PRZYKLENK, B ^{[1
]}

MATTHIAS, C ^{[1
]}

JUNGWIRTH, R ^{[1
]}

BERTELE, RM ^{[1
]}

HARMS, K ^{[1
]}

机构：

[1] DR VON HAUNERSCHES KINDERSPITAL,W-8000 MUNICH 2,GERMANY

来源：

INFECTION | 1990年 / 18卷 / 02期

关键词：

D O I：

10.1007/BF01641436

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Susceptibility in vitro of 179 staphylococcal strains from 107 cystic fibrosis patients against 31 antibiotics indicates that only teicoplanin, vancomycin and netilmicin were active against all strains. The use of betalactam antibiotics is impaired by 11.7% of methicillin-resistant strains. The bactericidal kinetics of cephalexin and flucloxacillin as determined in a pharmacody-namic model demonstrates the killing of strains resistant to cephalexin (MIC 8 mg/l to 32 mg/l) by flucloxacillin. For the rational selection of antistaphylococcal antibiotics for cystic fibrosis patients, both the MIC of the isolates and the concentration of the antibotics in cystic fibrosis patients have to be considered. © 1990 MMV Medizin Verlag GmbH München.

引用

页码：126 / 130

页数：5

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