IMPROVEMENT OF ANTISENSE OLIGONUCLEOTIDES BY SYNTHETIC MODIFICATIONS

被引：0
|
作者：
DEMESMAEKER, A
WALDNER, A
FRITSCH, V
WOLF, RM
机构：
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷
关键词：
OLIGONUCLEOTIDES; ANTISENSE; BACKBONE MODIFICATION; AMIDES; UREAS; CARBAMATES; ENZYMATIC STABILITY; MELTING TEMPERATURE; DUPLEX FORMATION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：S479 / S484
页数：6
相关论文
共 50 条
  • [1] SYNTHETIC MODIFICATIONS OF ANTISENSE OLIGONUCLEOTIDES - NOVEL BACKBONE REPLACEMENTS WITH IMPROVED PROPERTIES
    DEMESMAEKER, A
    WALDNER, A
    FRITSCH, V
    LEBRETON, J
    WOLF, RM
    BULLETIN DES SOCIETES CHIMIQUES BELGES, 1994, 103 (12): : 705 - 717
  • [2] Backbone modifications for antisense oligonucleotides
    DeMesmaeker, A
    Waldner, A
    Wendeborn, S
    Wolf, RM
    PURE AND APPLIED CHEMISTRY, 1997, 69 (03) : 437 - 440
  • [3] Antisense oligonucleotides: modifications and clinical trials
    Sharma, Vivek K.
    Sharma, Raman K.
    Singh, Sunil K.
    MEDCHEMCOMM, 2014, 5 (10) : 1454 - 1471
  • [4] Heterocyclic modifications of oligonucleotides and antisense technology
    Herdewijn, P
    ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 2000, 10 (04): : 297 - 310
  • [5] Synthetic oligonucleotides: The development of antisense therapeutics
    Monteith, DK
    Levin, AA
    TOXICOLOGIC PATHOLOGY, 1999, 27 (01) : 8 - 13
  • [6] Structural modifications toward improved antisense oligonucleotides
    Matteucci, M
    PERSPECTIVES IN DRUG DISCOVERY AND DESIGN, 1996, 4 : 1 - 16
  • [7] Design and structure of backbone modifications in antisense oligonucleotides.
    Wolf, RM
    DeMesmaeker, A
    Waldner, A
    Wendeborn, S
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 384 - COMP
  • [8] Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides
    Agrawal, S
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1489 (01): : 53 - 68
  • [9] CHEMICAL MODIFICATIONS TO IMPROVE UPTAKE AND BIOAVAILABILITY OF ANTISENSE OLIGONUCLEOTIDES
    MANOHARAN, M
    JOHNSON, LK
    MCGEE, DPC
    GUINOSSO, CJ
    RAMASAMY, K
    SPRINGER, RH
    BENNETT, CF
    ECKER, DJ
    VICKERS, T
    COWSERT, L
    COOK, PD
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 660 : 306 - 309
  • [10] Synthetic antisense oligonucleotides: Principles and antileukemic activity
    Morelli, S
    Quattrone, A
    Schiavone, N
    Calastretti, A
    Bevilacqua, A
    Tomasini, S
    Nicolin, A
    ONCOLOGY REPORTS, 1997, 4 : 219 - 225
12345