OPTIMIZATION OF SECONDARY CHEMICAL-EQUILIBRIA IN LIQUID-CHROMATOGRAPHY - THEORY AND VERIFICATION

被引：59

作者：

FOLEY, JP ^{[1
]}

MAY, WE ^{[1
]}

机构：

[1] NBS,CTR ANALYT CHEM,GAITHERSBURG,MD 20899

来源：

ANALYTICAL CHEMISTRY | 1987年 / 59卷 / 01期

关键词：

OPTIMIZATION;

D O I：

10.1021/ac00128a022

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A general theory for the optimization of secondary chemical equilibria in liquid chromatography (SCE-LC) is presented. Equations that predict the optimum mobile phase conditions are derived explicitly for the equilibrium AX reversible reaction A plus X. The selectivity of SCE-LC has been substantially underestimated because nonoptimum mobile phase conditions were employed in previous selectivity estimates. The theory is experimentally verified for acid-base equilibria.

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页码：102 / 109

页数：8

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