Iodine-Refractory Thyroid Carcinoma

被引：4
作者：
Ganti, Apar Kishor [1 ]
Cohen, Ezra E. W. [2 ]
机构：
[1] Univ Nebraska, Med Ctr, Dept Internal Med, Div Oncol Hematol, Omaha, NE 68198 USA
[2] Univ Chicago, Dept Med, Sect Hematol Oncol, 5841 S Maryland Ave,MC 2115, Chicago, IL 60637 USA
来源：
REVIEWS ON RECENT CLINICAL TRIALS | 2006年 / 1卷 / 02期
关键词：
D O I：
10.2174/157488706776876526
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The management of thyroid carcinomas commonly involves thyroidectomy, radioactive iodine to ablate any thyroid remnant in patients at high risk of recurrence, and suppressive thyroid hormone replacement. However many tumors will de-differentiate and become refractory to radioactive iodine. After progressive dedifferentiation the prognosis for these patients is poor, with no curative options available as these tumors respond poorly to currently available agents. In this review, we examine the unique biology of thyroid cancer and the various intracellular pathways which are currently the subject of intensive focus. Trials evaluating the efficacy of cytotoxic chemotherapeutic agents in iodinerefractory thyroid carcinoma and current novel therapeutic approaches will be emphasized.
引用
收藏
页码：133 / 141
页数：9
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