INDAZOLE AND INDOLINE AS AROMATIC BIOISOSTERES IN THE IMIDAZOLE CLASS OF SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS

被引：7

作者：

BERMUDEZ, J ^{[1
]}

KING, FD ^{[1
]}

SANGER, GJ ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80418-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and 5-HT3 receptor antagonist activity of imidazole derivatives of 3-keto-indazoles, and 3,3-dimethylindolin-1-yl and o-methoxyphenyl amides is described. Results demonstrate that indazole and indoline are effective bioisosteres in the imidazole class of 5-HT3 receptor antagonists.

引用

页码：1509 / 1512

页数：4

共 11 条

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