NOVEL AVERMECTINS PRODUCED BY MUTATIONAL BIOSYNTHESIS

被引：137

作者：

DUTTON, CJ ^{[1
]}

GIBSON, SP ^{[1
]}

GOUDIE, AC ^{[1
]}

HOLDOM, KS ^{[1
]}

PACEY, MS ^{[1
]}

RUDDOCK, JC ^{[1
]}

BULOCK, JD ^{[1
]}

RICHARDS, MK ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CHEM,WEIZMANN MICROBIAL LAB,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 03期

关键词：

D O I：

10.7164/antibiotics.44.357

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.

引用

页码：357 / 365

页数：9

共 26 条

[1] AVERMECTINS - STRUCTURE DETERMINATION [J].

ALBERSSCHONBERG, G ;

ARISON, BH ;

CHABALA, JC ;

DOUGLAS, AW ;

ESKOLA, P ;

FISHER, MH ;

LUSI, A ;

MROZIK, H ;

SMITH, JL ;

TOLMAN, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (14) :4216-4221

[2] ON SYNTHESIS AND PROPERTIES OF 1-THIACYCLOBUTANE-3-CARBOXYLIC ACID 1-OXIDE [J].

ALLENMARK, S .

ACTA CHEMICA SCANDINAVICA, 1964, 18 (09) :2197-+

[3]

BULOCK JD, 1986, Patent No. 214731

[4] IVERMECTIN - A REVIEW OF EFFICACY AND SAFETY [J].

CAMPBELL, WC ;

BENZ, GW .

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 1984, 7 (01) :1-16

[5] MACROLIDE BIOSYNTHESIS .4. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO ERYTHROMYCIN [J].

CANE, DE ;

YANG, CC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) :1255-1257

[6] BIOSYNTHETIC ORIGIN OF THE CARBON SKELETON AND OXYGEN-ATOMS OF THE AVERMECTINS [J].

CANE, DE ;

LIANG, TC ;

KAPLAN, L ;

NALLIN, MK ;

SCHULMAN, MD ;

HENSENS, OD ;

DOUGLAS, AW ;

ALBERSSCHONBERG, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (12) :4110-4112

[7] SYNTHESIS AND LIQUID-CRYSTAL PROPERTIES OF COMPOUNDS INCORPORATING CYCLOBUTANE, SPIRO[3.3]HEPTANE AND DISPIRO[3.1.3.1]DECANE RINGS [J].

CHAN, LKM ;

GEMMELL, PA ;

GRAY, GW ;

LACEY, D ;

TOYNE, KJ .

MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 1987, 147 :113-139

[8] FURTHER-STUDIES ON THE BIOSYNTHESIS OF THE AVERMECTINS [J].

CHEN, TS ;

ARISON, BH ;

GULLO, VP ;

INAMINE, ES .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1989, 4 (03) :231-237

[9]

CHEN TS, 1989, ARCH BIOCH BIPHYS, V269, P5444

[10]

Claeson G., 1967, ARK KEMI, V28, P167

← 1 2 3 →