SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW PYRIDAZINE DERIVATIVES

被引：6

作者：

ABDELGHANI, E

ASSY, MG

MOUSTAFA, HY

机构：

[1] Chemistry Department, Faculty of Science, Zagazig University, Zagazig

来源：

MONATSHEFTE FUR CHEMIE | 1995年 / 126卷 / 11期

关键词：

PYRIDAZINONE; PYRIDAZINETHIONE; CHLOROPYRIDIAZINE;

D O I：

10.1007/BF00824306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of beta-aroyl-alpha-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of 2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. The in vitro antibacterial screening reveals moderate activities against certain bacteria.

引用

页码：1265 / 1270

页数：6

共 9 条

[1]

BALYAN KV, 1954, ZH OBSHCH KHIM+, V24, P238

[2] STRUCTURAL AND SOLVENT ELECTROLYTE EFFECTS ON THE SELECTIVITY AND EFFICIENCY OF THE ANODIC-OXIDATION OF PARA-SUBSTITUTED AROMATIC ETHERS - AN EFFICIENT ROUTE TO QUINOL ETHER KETALS AND QUINOL ETHERS [J].

CAPPARELLI, MP ;

DESCHEPPER, RE ;

SWENTON, JS .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (22) :4953-4961

[3]

Kamiya S, 1966, Yakugaku Zasshi, V86, P1099

[4] BETA-AROYLACRYLIC ACIDS [J].

PAPA, D ;

SCHWENK, E ;

VILLANI, F ;

KLINGSBERG, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (10) :3356-3360

[5]

SAYED G H, 1984, Egyptian Journal of Chemistry, V27, P757

[6]

SAYED GH, 1990, INDIAN J CHEM B, V29, P72

[7]

SAYED GH, 1986, EGYPT J CHEM, V29, P433

[8]

SAYED GH, 1984, J CHEM SOC PAKISTAN, V6, P95

[9]

SAYED GH, 1991, EGYPT J CHEM, V34, P73

← 1 →