PH-DEPENDENT HYDROLYSIS AND DRUG-RELEASE OF CHITOSAN POLYETHER INTERPENETRATING POLYMER NETWORK HYDROGEL

被引：45
作者：
YAO, KD
PENG, T
XU, MX
YUAN, C
GOOSEN, MFA
ZHANG, QQ
REN, L
机构：
[1] QUEENS UNIV,DEPT CHEM ENGN,KINGSTON K7L 3N6,ONTARIO,CANADA
[2] CHINESE ACAD MED SCI,INST BIOMED ENGN,TIANJIN 300192,PEOPLES R CHINA
来源：
POLYMER INTERNATIONAL | 1994年 / 34卷 / 02期
关键词：
HYDROLYSIS; DRUG RELEASE; IPN; GEL; SWELLING;
D O I：
10.1002/pi.1994.210340213
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This paper describes a novel hydrogel based on crosslinked chitosan with glutaraldehyde interpenetrating polyether polymer network. The gel can hydrolyse in acid at 37-degrees-C due to the cleavage of imine bonds within the network. At pH greater-than-or-equal-to 7, there is no hydrolysis. The pH-dependent release of cimetidine from the gel was also investigated.
引用
收藏
页码：213 / 219
页数：7
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