INFLUENCE OF LIPOPHILIC N-ACYL DERIVATIVES OF D-GLUCOSAMINE IN THE GALACTOSYLATION WITH GALACTOSYLTRANSFERASE

被引：0

作者：

ATS, SC ^{[1
]}

LEHMANN, J ^{[1
]}

机构：

[1] UNIV FREIBURG,INST ORGAN CHEM & BIOCHEM,D-79104 FREIBURG,GERMANY

来源：

LIEBIGS ANNALEN DER CHEMIE | 1994年 / 09期

关键词：

BETA-GALACTOSYLTRANSFERASE; ENZYMES; CARBOHYDRATES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several D-glucosamine derivatives varying in N-acylation were used as acceptor substrates for galactosyltransferase and the relative rates of their galactosylation by UDP-Gal measured. One of them, 2-deoxy-2-[4-(2-indolyl)butyramido]-D-glucose (6) was newly synthesised and galactosylated at a significantly enhanced rate (14 times) in competition with GlcNAc as standard. Generally an increased lipophilicity increases the relative rate, provided the N-acyl group in question does not sterically hinder acceptor binding because it increases the bulk of the pyranose ring system.

引用

页码：951 / 953

页数：3

共 18 条

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