SPECIFIC DNA-RNA HYBRID BINDING BY ZINC-FINGER PROTEINS

被引：82

作者：

SHI, YG ^{[1
]}

BERG, JM ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT BIOPHYS & BIOPHYS CHEM, BALTIMORE, MD 21205 USA

来源：

SCIENCE | 1995年 / 268卷 / 5208期

关键词：

D O I：

10.1126/science.7536342

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zinc finger proteins of the Cys(2)His(2) type represent a large class of proteins that have been assumed to function by means of specific interactions with DNA. Experiments motivated by structural characteristics of zinc finger protein-DNA complexes revealed that certain zinc finger proteins bound DNA-RNA hybrids with affinities comparable to or greater than those for DNA duplexes. The interactions between the zinc finger proteins and the DNA-RNA hybrids were dependent on which strand was RNA and were sequence-specific. Thus, interactions with DNA-RNA hybrids should be considered with regard to the biological roles of zinc finger proteins.

引用

页码：282 / 284

页数：3

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