LARGER SCALE PREPARATION OF OPTICALLY-ACTIVE ALLYLIC ALCOHOLS

被引：26
|
作者：
BALMER, E
GERMAIN, A
JACKSON, WP
LYGO, B
机构：
[1] WELLCOME FDN LTD,PROC RES CHEM DEV,B427,TEMPLE HILL,DARTFORD,KENT,ENGLAND
[2] UNIV SALFORD,DEPT CHEM,SALFORD M5 4WT,LANCS,ENGLAND
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 04期
关键词：
D O I：
10.1039/p19930000399
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical synthesis of optically-active allylic alcohols from 2,3-epoxytoluene-p-sulfonates by the in situ formation of the epoxy iodides and their subsequent reduction with zinc-copper couple has been established. Application of this procedure to the larger-scale synthesis of (S)-(+)-but-3-en-2-ol from (2S,3S)-3-methylglycidyl toluene-p-sulfonate has also been investigated.
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页码：399 / 400
页数：2
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