PREPARATION AND STUDY OF RELEASE KINETICS OF ROSIN PENTAERYTHRITOL ESTER MICROCAPSULES

被引:10
作者
SHEOREY, DS
DORLE, AK
机构
[1] Department of Pharmaceutical Sciences, Nagpur University, Nagpur
关键词
Esters;
D O I
10.3109/02652049409040434
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release characteristics in simulated gastric and intestinal fluids. The microcapsule size increased as the acid value of the ester decreased. The release of the drug was studied by using first-order, Higuchi and Hixon-Crowell cube root models. The release mechanism of the microcapsules is discussed.
引用
收藏
页码:11 / 17
页数:7
相关论文
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