ETIOLOGY OF BREAST-CARCINOMA - NO APPARENT ROLE FOR PAPILLOMAVIRUS TYPES-6/11/16/18

被引：54
作者：
BRATTHAUER, GL
TAVASSOLI, FA
OLEARY, TJ
机构：
[1] ARMED FORCES INST PATHOL, DEPT CELLULAR PATHOL, 14TH ST & ALASKA AVE NW, WASHINGTON, DC 20306 USA
[2] ARMED FORCES INST PATHOL, DEPT GYNECOL & BREAST PATHOL, WASHINGTON, DC 20306 USA
来源：
PATHOLOGY RESEARCH AND PRACTICE | 1992年 / 188卷 / 03期
关键词：
ADENOCARCINOMA; PAPILLARY CARCINOMA; INFILTRATING DUCTAL CARCINOMA; BREAST; HUMAN PAPILLOMAVIRUS;
D O I：
10.1016/S0344-0338(11)81229-X
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A recent study has shown that human papillomavirus (HPV) types 16 and 18 can immortalize normal breast epithelium, and raised the possibility that HPV may be etiologically related to some cases of breast cancer. In order to investigate this possibility, we performed polymerase chain reaction (PCR) assays for HPV types 6, 11, 16 and 18 in 15 papillomas, 15 papillary carcinomas, and 13 infiltrating ductal carcinomas of the breast. No HPV-related DNA sequences were identified by Southern blotting of the PCR products. It therefore seems unlikely that a significant percentage of human breast carcinomas is etiologically related to infection with one of these HPV types.
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页码：384 / 386
页数：3
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