CARBOHYDRATE-PEPTIDE LINKAGE IN GLYCOPROTEINS

被引：174

作者：

AUBERT, JP ^{[1
]}

BISERTE, G ^{[1
]}

LOUCHEUXLEFEBVRE, MH ^{[1
]}

机构：

[1] INSERM, INST RECH CANC LILLE, F-59020 LILLE, FRANCE

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1976年 / 175卷 / 02期

关键词：

D O I：

10.1016/0003-9861(76)90528-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The secondary structure of the peptide segment around the carbohydrate-peptide linkage in glycoproteins was predicted by using the Chou and Fasman determination. Such a study was carried out for 9 O-glycosidically linkages and 28 N-glycosidically linkages. In the case of O-glycosidically linkages, the residue Ser or Thr involved in the linkage always belongs to a .beta.-turn. In the case of N-glycosidically linkages, 19 out of the 28 Asn studied belong to a .beta.-turn. A predicted determination concerning the whole protein moiety of 9 glycoproteins in order to obtain some information concerning the spatial organization of the entire glycoprotein was carried out also. It seems that the carbohydrate moiety appears to be situated on the outer surface of the glycoprotein.

引用

页码：410 / 418

页数：9

共 31 条

[1]

AUBERT JP, 1976, ARCH BIOCHEM BIOPHYS, V175

[2]

CHARET P, 1969, CR ACAD SCI D NAT, V269, P1019

[3] CONFORMATIONAL PARAMETERS FOR AMINO-ACIDS IN HELICAL, BETA-SHEET, AND RANDOM COIL REGIONS CALCULATED FROM PROTEINS [J].