STUDY OF PARAMETERS IMPORTANT IN THE SPHERONIZATION PROCESS

被引：50

作者：

BAERT, L

VERMEERSCH, H

REMON, JP

SMEYERSVERBEKE, J

MASSART, DL

机构：

[1] STATE UNIV GHENT,PHARMACEUT TECHNOL LAB,HARELBEKESTR 72,B-9000 GHENT,BELGIUM

[2] FREE UNIV BRUSSELS,INST PHARMACEUT,B-1090 BRUSSELS,BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 96卷 / 1-3期

关键词：

SPHERONISATION; PARAMETER ANALYSIS; QUALITY; PARETO ANALYSIS;

D O I：

10.1016/0378-5173(93)90231-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An experimental design was used to determine the influence of parameters that are important in the extrusion-spheronisation process. The parameters tested were water content of binary mixtures of Avicel PH 101(R)/water, spheroniser speed and spheronisation time. They appeared to have a significant influence on the quality of the spheres. By using a Pareto analysis, optimal parameter settings for water content, spheroniser speed and spheronising time were obtained.

引用

收藏

页码：225 / 229

页数：5

相关论文

共 10 条

[1] INSTRUMENTATION OF A GRAVITY FEED EXTRUDER AND THE INFLUENCE OF THE COMPOSITION OF BINARY AND TERNARY MIXTURES ON THE EXTRUSION FORCES [J].

BAERT, L ;

FANARA, D ;

DEBAETS, P ;

REMON, JP .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1991, 43 (11) :745-749

[2] CORRELATION OF EXTRUSION FORCES, RAW-MATERIALS AND SPHERE CHARACTERISTICS [J].

BAERT, L ;

FANARA, D ;

REMON, JP ;

MASSART, D .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1992, 44 (08) :676-678

[3] CHARACTERIZATION OF THE SPHERICITY OF PARTICLES BY THE ONE PLANE CRITICAL STABILITY [J].

CHAPMAN, SR ;

ROWE, RC ;

NEWTON, JM .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (07) :503-505

[4] A FACTORIAL APPROACH TO PROCESS VARIABLES OF EXTRUSION-SPHERONIZATION OF WET POWDER MASSES [J].

CHARIOT, M ;

FRANCES, J ;

LEWIS, GA ;

MATHIEU, D ;

LUU, RPT ;

STEVENS, HNE .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1987, 13 (9-11) :1639-1649

[5] SOME FACTORS INFLUENCING PELLET CHARACTERISTICS MADE BY AN EXTRUSION/SPHERONISATION PROCESS .1. EFFECTS ON SIZE CHARACTERISTICS AND MOISTURE-CONTENT DECREASE OF PELLETS [J].

HASZNOS, L ;

LANGER, I ;

GYARMATHY, M .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1992, 18 (04) :409-437

[6] PROGRAM FOR PARETO-OPTIMALITY IN MULTICRITERIA PROBLEMS [J].

KELLER, HR ;

MASSART, DL .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 1990, 9 (08) :251-253

[7]

LOVGREN K, 1989, 8TH P PHARM TECHN C, P308

[8] USE OF FACTORIAL DESIGN TO EVALUATE GRANULATIONS PREPARED BY SPHERONIZATION [J].

MALINOWSKI, HJ ;

SMITH, WE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (10) :1688-1692

[9]

REYNOLDS AD, 1970, MANUF CHEMIST, V41, P40

[10] INTRODUCTION OF MULTICRITERIA DECISION-MAKING IN OPTIMIZATION PROCEDURES FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATIONS [J].

SMILDE, AK ;

KNEVELMAN, A ;

COENEGRACHT, PMJ .

JOURNAL OF CHROMATOGRAPHY, 1986, 369 (01) :1-10