A BIOMIMETIC AND FULLY REGIOCONTROLLED TOTAL SYNTHESIS OF (+/-)-COLCHICINE

被引：32

作者：

BANWELL, MG

LAMBERT, JN

MACKAY, MF

GREENWOOD, RJ

机构：

[1] LA TROBE UNIV,DEPT CHEM,BUNDOORA,VIC 3083,AUSTRALIA

[2] UNIV MELBOURNE,SCH CHEM,PARKVILLE,VIC 3052,AUSTRALIA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 14期

关键词：

D O I：

10.1039/c39920000974

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first fully regiocontrolled total synthesis of the alkaloid colchicine 1 is described; the key step of the reaction sequence is the efficient biomimetic conversion of the sigma-homo-o-benzoquinone monoacetal 11 into the alpha-tropolone-O-methyl ether 13.

引用

收藏

页码：974 / 975

页数：2

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