THE TEMPERATURE EFFECT ON IN-VITRO PENETRATION OF SODIUM LAURYL SULFATE AND NICKEL CHLORIDE THROUGH HUMAN SKIN

被引:0
作者
EMILSON, A
LINDBERG, M
FORSLIND, B
机构
[1] UNIV HOSP UPPSALA, DEPT DERMATOL, UPPSALA, SWEDEN
[2] KAROLINSKA HOSP, DEPT CLIN IMMUNOL, S-10401 STOCKHOLM 60, SWEDEN
关键词
SKIN PENETRATION; DETERGENTS; SLS; IRRITANT CONTACT DERMATITIS;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Irritant contact dermatitis is a major problem in dermatology. One important group of substances causing irritant dermatitis is detergents. Exposure of the skin to detergents is frequent in both work and domestic environments. In the present paper we have studied how the penetration through the skin, and thus the effect, of the detergent sodium lauryl sulfate (SLS) is altered when the temperature is raised from 22-degrees-C to 40-degrees-C or 60-degrees-C. We found that the penetration of sodium lauryl sulfate increased with increasing temperature. When comparing the increased penetration of sodium lauryl sulfate with the change in NiCl penetration at the same temperatures, we found that the increase in penetration was more pronounced for the detergent. This implies that the detergent also had a different effect on the structure and function of the epidermal barrier itself. The results underline the importance of chosing the right (low) temperature when working with detergent solutions to reduce the risk of developing irritant contact reactions.
引用
收藏
页码:203 / 207
页数:5
相关论文
共 31 条
[1]  
AGNER T, 1992, ACTA DERM-VENEREOL, P1
[2]   MECHANISM OF PERCUTANEOUS ABSORPTION .3. EFFECT OF TEMPERATURE ON TRANSPORT OF NON-ELECTROLYTES ACROSS SKIN [J].
BLANK, IH ;
SCHEUPLEIN, RJ ;
MACFARLANE, DJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1967, 49 (06) :582-+
[4]   LIMITATIONS OF HAIRLESS MOUSE SKIN AS A MODEL FOR INVITRO PERMEATION STUDIES THROUGH HUMAN-SKIN - HYDRATION DAMAGE [J].
BOND, JR ;
BARRY, BW .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1988, 90 (04) :486-489
[5]  
BRAUNFALCO O, 1990, SKIN CLEANSING SYNTH, P3
[6]  
Bronaugh RL, 1989, PERCUTANEOUS ABSORPT, P239
[7]  
ELIAS PM, 1983, J INVEST DERMATOL, V80, pS44, DOI 10.1038/jid.1983.12
[8]   STRATUM-CORNEUM LIPID REMOVAL BY SURFACTANTS - RELATION TO INVIVO IRRITATION [J].
FROEBE, CL ;
SIMION, FA ;
RHEIN, LD ;
CAGAN, RH ;
KLIGMAN, A .
DERMATOLOGICA, 1990, 181 (04) :277-283
[9]   STRATUM-CORNEUM LIPID PHASE-TRANSITIONS AND WATER BARRIER PROPERTIES [J].
GOLDEN, GM ;
GUZEK, DB ;
KENNEDY, AH ;
MCKIE, JE ;
POTTS, RO .
BIOCHEMISTRY, 1987, 26 (08) :2382-2388
[10]   INTERACTION OF SURFACTANTS WITH BILAYER OF NEGATIVELY CHARGED LIPID - EFFECT ON GEL-TO-LIQUID-CRYSTALLINE PHASE-TRANSITION OF DILAUROYLPHOSPHATIDIC ACID VESICLE MEMBRANE [J].
INOUE, T ;
IWANAGA, T ;
FUKUSHIMA, K ;
SHIMOZAWA, R ;
SUEZAKI, Y .
CHEMISTRY AND PHYSICS OF LIPIDS, 1988, 48 (3-4) :189-196