SEPHADEX-INDUCED GRANULOMATOUS ALVEOLITIS IN RAT - EFFECTS OF ANTIGEN MANIPULATION

被引：10
作者：
BJERMER, L
SANDSTROM, T
SARNSTRAND, B
BRATTSAND, R
机构：
[1] UNIV HOSP UMEA, DEPT LUNG MED, UMEA, SWEDEN
[2] NATL INST OCCUPAT HLTH, DIV MED, UMEA, SWEDEN
[3] ASTRA DRACO AB, LUND, SWEDEN
来源：
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 1994年 / 25卷 / 01期
关键词：
BRONCHOALVEOLAR LAVAGE; ALLERGIC ALVEOLITIS; EOSINOPHILS; LYMPHOCYTES; SEPHADEX; ORGANIC DUSTS;
D O I：
10.1002/ajim.4700250119
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology. (C) 1994 Wiley-Liss, Inc.
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页码：73 / 78
页数：6
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