MYELOPATHY FOLLOWING HYPERFRACTIONATED ACCELERATED RADIOTHERAPY FOR ANAPLASTIC THYROID-CARCINOMA

被引：60

作者：

WONG, CS ^{[1
]}

VANDYK, J ^{[1
]}

SIMPSON, WJ ^{[1
]}

机构：

[1] PRINCESS MARGARET HOSP, DEPT CLIN PHYS, TORONTO M4X 1K9, ONTARIO, CANADA

来源：

RADIOTHERAPY AND ONCOLOGY | 1991年 / 20卷 / 01期

关键词：

THYROID CARCINOMA; HYPERFRACTIONATION; RADIATION MYELOPATHY;

D O I：

10.1016/0167-8140(91)90105-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

From 1975 to 1982, 32 patients with a diagnosis of anaplastic carcinoma of the thyroid were entered into a protocol of hyperfractionated accelerated radiotherapy. The tumor dose was 30-45 Gy at 1 Gy per fraction given 4 times a day at 3-h intervals. The results were disappointing with a median survival of less than 6 months. Two patients developed radiation myelopathy at 8 and 13 months, total spinal cord dose being 39.9 and 48.3 Gy, respectively. The risk of spinal cord damage was much higher than expected. The possible radiobiological causes and clinical implications are discussed.

引用

页码：3 / 9

页数：7

共 22 条

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