MICROBIAL REDUCTION OF 2-CHLORO-3-ARYL-3-OXOPROPIONIC ACID-ESTERS

被引：24

作者：

CABON, O

LARCHEVEQUE, M

BUISSON, D

AZERAD, R

机构：

[1] ECOLE NORM SUPER,CHIM LAB,CNRS,UNITE PROPRE,24 RUE LHOMOND,F-75231 PARIS 05,FRANCE

[2] UNIV R DESCARTES,CNRS,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 48期

关键词：

2-CHLORO-3-KETOESTERS; 2,3-EPOXYESTERS; MICROBIAL REDUCTIONS; BAKER YEAST; MUCOR-RACEMOSUS; RHODOTORULA-GLUTINIS;

D O I：

10.1016/S0040-4039(00)60181-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Chloro-3-aryl-3-oxopropionic acid esters are reduced by microorganisms to syn- and/or anti-2-chloro-3-hydroxy-3-arylpropionates, in competition with dechlorination and decarboxylation reactions. Using selected strains, it is possible to obtain enantiomerically pure chlorohydroxyesters, which were converted to the corresponding phenylglycidic esters with high stereospecificity.

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页码：7337 / 7340

页数：4

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