EXPERIMENTAL ACUTE SELENIUM INTOXICATION IN LAMBS

被引：39
|
作者：
SMYTH, JBA
WANG, JH
BARLOW, RM
HUMPHREYS, DJ
ROBINS, M
STODULSKI, JBJ
机构：
[1] Department of Veterinary Pathology, The Royal Veterinary College, Hatfield, Herts AL9 7TA, Hawkshead Lane, North Mymms
来源：
JOURNAL OF COMPARATIVE PATHOLOGY | 1990年 / 102卷 / 02期
关键词：
D O I：
10.1016/S0021-9975(08)80125-9
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The toxic effects or 5 mg per kg body weight of selenium given as sodium seIenite orally or parenterally to growing lambs were examined. There was considerable individual variatiori in both susceptibility to intoxication and the degree of pathological change displayed. The results affirm the previously reported deleterious effects on the cardiovascular, respiratory and urinary systems and highlight damage to secondary lymphoid tissue in various organs. The use of a histochemical method for detecting selenium bonds demonstrated correlation between the density of reaction-product and histopathological changes within tissues, and showed the distribution of selenium in other tissues in which the gross and histopathological findings were non-specific or minimal. © 1990 Academic Press Limited.
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收藏
页码：197 / 209
页数：13
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