ASYMMETRIC-SYNTHESIS OF ENANTIOMERICALLY PURE 4'-FLUOROALKYL-2',3'-DIDEOXY NUCLEOSIDES

被引：9
作者：
BRAVO, P [1 ]
MELE, A [1 ]
SALANI, G [1 ]
VIANI, F [1 ]
机构：
[1] POLITECN MILAN,DIPARTIMENTO CHIM,CNR,CTR STUDIO SUNTANZE ORGAN NAT,I-20131 MILAN,ITALY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 13期
关键词：
D O I：
10.1016/S0960-894X(01)80569-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Elaboration of 2-(fluoromethyl)-2-[(4-methylphenylsulphinyl)methyl] oxirane (5), deriving from p-tolylmethyl sulphoxide (2), ethyl fluoroacetate (3) and diazomethane, to 4'-fluoromethyl lactol (10) followed by condensation with the activated thymine and reductive debenzylation allowed the obtainment of 4'-fluoromethyl-2',3'-dideoxythymidine (1).
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页码：1577 / 1580
页数：4
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