IMPROVEMENTS IN FLOWABILITY AND COMPRESSIBILITY OF PHARMACEUTICAL CRYSTALS FOR DIRECT TABLETTING BY SPHERICAL CRYSTALLIZATION WITH A 2-SOLVENT SYSTEM

被引：58

作者：

KAWASHIMA, Y

CUI, F

TAKEUCHI, H

NIWA, T

HINO, T

KIUCHI, K

机构：

[1] SHENYANG COLL PHARM,SHENYANG,PEOPLES R CHINA

[2] RHONE POULENC JAPAN LTD,MINATO KU,TOKYO 107,JAPAN

来源：

POWDER TECHNOLOGY | 1994年 / 78卷 / 02期

关键词：

D O I：

10.1016/0032-5910(93)02772-3

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Pharmaceutical crystals for direct tabletting were agglomerated by the spherical crystallization technique with a two-solvent system, i.e. good and poor solvents for dissolving the drug, to improve their micromeritic properties, such as flowability, packability and compressibility. Flowability and packability of the agglomerates were investigated by measuring tapped densities and interparticle frictions when sheared. Compressibility was investigated by analyzing the compaction process by the Heckel equation and the mechanical strength of the resultant tablet, including tensile strength and capping index. Such micromeritic properties of the agglomerates were much improved due to their reduced interparticle friction and increased interparticle bonding on tabletting.

引用

页码：151 / 157

页数：7

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