GENETICS OF RENAL DAMAGE IN PRIMARY HYPERTENSION

被引：21

作者：

CUSI, D

TRIPODI, G

CASARI, G

ROBBA, C

BOLLINI, P

MERATI, G

BIANCHI, G

机构：

[1] SETTIMO MILANESE, PRASSIS RES INST, MILAN, ITALY

[2] UNIV MILAN, CHAIR NEPHROL, I-20122 MILAN, ITALY

[3] UNIV MILAN, POSTGRAD SCH NEPHROL, I-20122 MILAN, ITALY

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1993年 / 21卷 / 05期

关键词：

KIDNEY; HYPERTENSION; GENETICS; PATHOPHYSIOLOGY;

D O I：

10.1016/0272-6386(93)70092-D

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Little is known of the genetics of glomerular damage in essential hypertension in humans. The prevalence of endstage renal disease due to primary hypertension varies from 20% to 30% of all cases of renal failure to as low as 0.002%. This depends not only on differences in diagnostic criteria but also on different racial susceptibility to the disease as well as on different genetic backgrounds in different subsets of individuals of the same race. A review of the literature is provided, together with an example of how a point mutation that causes hypertension in Milan hypertensive rats can provide a model to analyze this issue correctly. © 1993, National Kidney Foundation, Inc.. All rights reserved.

引用

页码：2 / 9

页数：8

共 52 条

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ANDERSEN AR, 1983, DIABETOLOGIA, V25, P496

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