AGE STABILITY OF HUMAN BRAIN 5-HT TERMINALS STUDIED WITH [H-3] PAROXETINE BINDING

被引：0
作者：
ANDERSSON, A
SUNDMAN, I
MARCUSSON, J
机构：
[1] UMEA UNIV,DEPT INTERNAL MED,S-90187 UMEA,SWEDEN
[2] UMEA UNIV,DEPT PSYCHIAT,S-90187 UMEA,SWEDEN
来源：
GERONTOLOGY | 1992年 / 38卷 / 03期
关键词：
H-3]PAROXETINE BINDING; 5-HT UPTAKE SITES; HUMAN BRAIN;
D O I：
暂无
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The effect of age on serotonin uptake sites labeled with [H-3]paroxetine was studied in two sets of brains. The first set included 28 subjects (19 males and 9 females) between the ages 0 and 100 years. The cortex of cingulate gyrus and the amygdala were studied. No age-related changes in binding capacity (B(max)) or binding affinity (K(d)) were noted. In the second set, the frontal cor-tex and hypothalamus from 22 subjects (18 males and 4 females) between 16 and 75 years were studied. No age-related changes in the binding were observed. The interval between death and freezing of the tissue did not influence the binding. Regarding the [H-3]paroxetine binding as an indirect marker for 5-HT terminals, the data suggest a stability of 5-HT terminals with increasing age in the human brain.
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页码：127 / 132
页数：6
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