DIFFERENTIAL-DIAGNOSIS OF CNS LESIONS IN AIDS PATIENTS BY FDG-PET

被引:77
作者
VILLRINGER, K
JAGER, H
DICHGANS, M
ZIEGLER, S
POPPINGER, J
HERZ, M
KRUSCHKE, C
MINOSHIMA, S
PFISTER, HW
SCHWAIGER, M
机构
[1] DEPT NUCL MED, MUNICH, GERMANY
[2] CURATORIUM IMMUNEDEFICIENCY, MUNICH, GERMANY
[3] LMU, DEPT NEUROL, MUNICH, GERMANY
[4] UNIV MICHIGAN, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA
关键词
EMISSION COMPUTED TOMOGRAPHY; FLUORODEOXYGLUCOSE; CENTRAL NERVOUS SYSTEM; DISEASES; ACQUIRED IMMUNODEFICIENCY SYNDROME;
D O I
10.1097/00004728-199507000-00004
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: The aim of this study was to evaluate the potential of FDG-PET in the differential diagnosis of CNS lesions in patients with AIDS, particularly to differentiate between toxoplasmosis and lymphoma. Materials and Methods: We examined 11 AIDS patients, 6 with toxoplasmosis, 1 with a tuberculoma, and 4 with a primary CNS lymphoma. The FDG uptake within the lesion was compared with the uptake in a contralateral brain area [standardized uptake value (SUV)]. Results: In all subjects with cerebral infections (toxoplasmosis, tuberculoma), the SUV ratio was significantly (p < 0.05) lower than the SUV ratio in patients with lymphoma (range of 0.3-0.7 vs. 1.7-3.1) with no overlap of the uptake values. Conclusion: In conclusion, FDG-PET may help to characterize these lesions metabolically and play an important role in the clinical management of AIDS patients with CNS involvement.
引用
收藏
页码:532 / 536
页数:5
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