AN OVERVIEW ON MICROBIAL FIBRINOLYTIC PROTEASES

被引：6

作者：

Raju, E. Venkata Naga ^{[1
]}

Divakar, G. ^{[2
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Biotechnol, Guntur 522510, Andhra Pradesh, India

[2] Acharya & BM Reddy Coll Pharm, Dept Biotechnol & Microbiol, Bangalore 560107, Karnataka, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2014年 / 5卷 / 03期

关键词：

Microbial fibrinolytic proteases; screening; production; strain improvement; purification;

D O I：

10.13040/IJPSR.0975-8232.5(3).643-56

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microbial fibrinolytic proteases are of considerable interest in view of their specific activity and stability at biological pH. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. Further, strain improvement using mutagenesis and/or recombinant DNA technology can be applied to augment the efficiency of the producer strain to a commercial status. The various nutritional and environmental parameters affecting the production of fibrinolytic proteases are delineated. The purification and properties of these fibrinolytic proteases is discussed, and the use of fibrinolytic proteases is highlighted.

引用

页数：21