Centrality Analysis Methods for Biological Networks and Their Application to Gene Regulatory Networks

被引：219
|
作者：
Koschutzki, Dirk [1 ]
Schreiber, Falk [1 ,2 ]
机构：
[1] Leibniz Inst Plant Genet & Crop Plant Res IPK, Dept Mol Genet, D-06466 Gatersleben, Germany
[2] Univ Halle Wittenberg, Inst Comp Sci, D-06120 Halle, Germany
来源：
GENE REGULATION AND SYSTEMS BIOLOGY | 2008年 / 2卷
关键词：
network analysis; centralities; gene regulatory network; escherichia coli; network motif;
D O I：
10.4137/GRSB.S702
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The structural analysis of biological networks includes the ranking of the vertices based on the connection structure of a network. To support this analysis we discuss centrality measures which indicate the importance of vertices, and demonstrate their applicability on a gene regulatory network. We show that common centrality measures result in different valuations of the vertices and that novel measures tailored to specifi c biological investigations are useful for the analysis of biological networks, in particular gene regulatory networks.
引用
收藏
页码：193 / 201
页数：9
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