LEVELS OF AZITHROMYCIN AND ALPHA-1-ACID GLYCOPROTEIN IN SERUM IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA

被引：6

作者：

BOHTE, R ^{[1
]}

MATTIE, H ^{[1
]}

VANDERBROEK, PJ ^{[1
]}

机构：

[1] UNIV LEIDEN HOSP,DEPT INFECT DIS,2300 RC LEIDEN,NETHERLANDS

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 12期

关键词：

D O I：

10.1128/AAC.39.12.2801

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

After an oral dose of 500 mg of azithromycin in patients with community-acquired pneumonia, their serum concentrations ranged between 0.06 and 0.25 mg/liter during the first 12 hours; the calculated percentages of unbound drug varied between 45 and 86%. This study shows that in these patients, the total levels of azithromycin in serum are lower than those expected and that the percentage of bound drug is clinically irrelevant.

引用

页码：2801 / 2802

页数：2

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