NORADRENERGIC ALPHA-1 AND ALPHA-2 ANTAGONISTS BLOCK L-DOPA-INDUCED AIR-STEPPING IN NEONATAL RATS

被引：14
|
作者：
TAYLOR, LL
SICKLES, AE
STEHOUWER, DJ
VANHARTESVELDT, C
机构：
[1] Department of Psychology, University of Florida, Gainesrille
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 79卷 / 02期
关键词：
NORADRENALINE; PRAZOSIN; IDAZOXAN; LOCOMOTION; L-3,4-DIHYDROXYPHENYLALANINE; AIR-STEPPING;
D O I：
10.1016/0165-3806(94)90128-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Five-day-old rat pups suspended in air and administered L-3,4-dihydroxyphenylalanine (L-DOPA) engage in a highly stereotyped and coordinated locomotor behavior termed air-stepping. L-DOPA is a precursor for dopamine and noradrenaline and one or both of these neurotransmitters could play a role in L-DOPA-induced air-stepping. The role of noradrenaline was investigated by assessing the abilities of the alpha-1 noradrenergic receptor antagonist prazosin and the alpha-2 noradrenergic receptor antagonist idazoxan to block L-DOPA-induced air-stepping in 5-day-old rats. Both antagonists decreased the duration of air-stepping. In addition, prazosin altered the topography of air-stepping by interfering with coordination of the hindlimbs. The results suggest that alpha-1 and alpha-2 noradrenergic receptor subtypes are involved in L-DOPA-induced air-stepping.
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页码：242 / 248
页数：7
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