CIRCULATING SERUM INTERFERON AND ITS EFFECT ON THE ACTIVITY OF HUMAN NATURAL-KILLER-CELLS

被引：0

作者：

CHEKNEV, SB

ASHMANOVA, YG

PRITSKER, AD

LATYSHEVA, OL

机构：

[1] RUSSIAN ACAD MED SCI,NF GAMALEYA EPIDEMIOL & MICROBIOL INST,DEPT INTERFERONS,IMMUNOCHEM LAB,MOSCOW,RUSSIA

[2] NI PIROGOV MUNICIPAL HOSP 1,DEPT NEUROL,MOSCOW,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 12期

关键词：

CIRCULATING INTERFERON; NATURAL KILLER ACTIVITY;

D O I：

10.1007/BF02445738

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The interferon content in the plasma of 6 healthy donors and 10 patients with multiple sclerosis and the effect of an 1-h treatment of mononuclear cells with autologous plasma on their natural killer activity are studied in vitro using H-3-uridine-labeled (3 mu Ci/ml) human erythromyeloleukosis cells K-562. The serum interferon content in healthy donors is 2.3+/-0.82 IU/ml, whereas that in patients is higher: 5.2+/-0.8 IU/ml. Autologous plasma does not affect the activity of natural killer cells in vitro, whereas it increases the cytotoxicity of mononuclear cells obtained from patients with multiple sclerosis by 35-64%.

引用

页码：1311 / 1314

页数：4

共 19 条

[1] AUTOLOGOUS ENHANCEMENT BY INTERFERON OF NATURAL-KILLER ACTIVITY OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES
CHEKNEV, SB
ASHMANOVA, YG
PRITSKER, AD
LATYSHEVA, OL
YERSHOV, FI
KULBERG, AJ
MEDIATORS OF INFLAMMATION, 1994, 3 (05) : 341 - 346
[2] MODULATION BY INTERFERON ALPHA OF THE DECREASED NATURAL-KILLER ACTIVITY IN PATIENTS WITH GLIOBLASTOMA
LAPENA, P
ISASI, C
VAQUERO, J
MARTINEZ, R
ALVAREZMON, M
ACTA NEUROCHIRURGICA, 1991, 109 (3-4) : 109 - 113
[3] In vitro modulation of natural killer activity of human peripheral blood mononuclear cells against prostate tumor cell line
Sheikhi, A.
Saadati, K.
Salmani, R.
Yahaghi, N.
Sheikhi, A.
Siemens, D. R.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2011, 33 (04) : 700 - 708
[4] CADMIUM INHIBITS SPONTANEOUS (NK), ANTIBODY-MEDIATED (ADCC) AND IL-2-STIMULATED CYTOTOXIC FUNCTIONS OF NATURAL-KILLER-CELLS
CIFONE, MG
PROCOPIO, A
NAPOLITANO, T
ALESSE, E
SANTONI, G
SANTONI, A
IMMUNOPHARMACOLOGY, 1990, 20 (02): : 73 - 80
[5] Effect of an oral administration of Lactobacillus casei strain Shirota on the natural killer activity of blood mononuclear cells in aged mice
Hori, T
Kiyoshima, J
Yasui, H
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (02) : 420 - 422
[6] ANTIMETASTATIC EFFECT OF DEFIBRINOGENATION WITH BATROXOBIN DEPENDS ON THE NATURAL-KILLER ACTIVITY OF HOST IN MICE
SHIBUYA, M
NIITANI, H
AOYAMA, A
KAWACHI, S
NUKARIYA, N
BABA, M
IIZUKA, K
SAKAI, S
OHTSUKA, M
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1990, 116 (02) : 168 - 172
[7] Effect of kumquat (Fortunella crassifolia) pericarp on natural killer cell activity in vitro and in vivo
Nagahama, Kiyoko
Eto, Nozomu
Shimojo, Tomofumi
Kondoh, Tomomi
Nakahara, Keiko
Sakakibara, Yoichi
Fukui, Keiichi
Suiko, Masahito
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2015, 79 (08) : 1327 - 1336
[8] Lactobacillus strains induce TRAIL production and facilitate natural killer activity against cancer cells
Horinaka, Mano
Yoshida, Tatsushi
Kishi, Atsuko
Akatani, Kaoru
Yasuda, Takashi
Kouhara, Junji
Wakada, Miki
Sakai, Toshiyuki
FEBS LETTERS, 2010, 584 (03): : 577 - 582
[9] Effect of culture supernatants of endometriotic lesions, uterine endometrium and peritoneum from rats with experimental endometriosis on the natural killer activity of spleen cells
Mizumoto, Y
Hirata, J
Tokuoka, S
Furuya, K
Kikuchi, Y
Nagata, I
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1996, 41 (02) : 122 - 127
[10] PRODUCTION OF INTERLEUKIN-2 BY YAC-1 CELLS STIMULATED WITH INTERLEUKIN-1 AND ITS AUGMENTATION OF THE NATURAL-KILLER ACTIVITY
SUZUKI, Y
DAIMARU, O
NOTAKE, K
YOKOCHI, T
IMMUNOLOGY LETTERS, 1990, 26 (03) : 239 - 244

← 1 2 →