Immune aspects of the breast tumor microenvironment

被引：11

作者：

Chawla, Akhil ^{[1
]}

Alatrash, Gheath ^{[2
]}

Wu, Yun ^{[3
]}

Mittendorf, Elizabeth A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, 1400 Pressler St, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

BREAST CANCER MANAGEMENT | 2013年 / 2卷 / 03期

关键词：

D O I：

10.2217/BMT.13.15

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other. Technological advances have allowed investigators to better identify the specific immune cells present and immune-related gene signatures overexpressed in the tumor microenvironment. Increased knowledge of tumor immunology has allowed us to better understand how these cells and the developing tumor interact. Together, these advances have prompted the conduct of numerous studies investigating the prognostic and predictive significance of immune infiltrates.

引用

页码：231 / 244

页数：14

共 80 条

[1] High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates [J].

Alexe, Gabricla ;

Dalgin, Gul S. ;

Scanfeld, Daniel ;

Tamayo, Pablo ;

Mesirov, Jill P. ;

DeLisi, Charles ;

Harris, Lyndsay ;

Barnard, Nicola ;

Martel, Maritza ;

Levine, Arnold J. ;

Ganesan, Shridar ;

Bhanot, Gyan .

CANCER RESEARCH, 2007, 67 (22) :10669-10676

[2] The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance [J].

Allavena, Paola ;

Sica, Antonio ;

Garlanda, Cecilia ;

Mantovani, Alberto .

IMMUNOLOGICAL REVIEWS, 2008, 222 :155-161

[3] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[4] Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? [J].

Arnould, L ;

Gelly, M ;

Penault-Llorca, F ;

Benoit, L ;

Bonnetain, F ;

Migeon, C ;

Cabaret, V ;

Fermeaux, V ;

Bertheau, P ;

Garnier, J ;

Jeannin, JF ;

Coudert, B .

BRITISH JOURNAL OF CANCER, 2006, 94 (02) :259-267

[5] Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse [J].

Bates, Gaynor J. ;

Fox, Stephen B. ;

Han, Cheng ;

Leek, Russell D. ;

Garcia, Jose F. ;

Harris, Adrian L. ;

Banham, Alison H. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (34) :5373-5380

[6] Molecular Anatomy of Breast Cancer Stroma and Its Prognostic Value in Estrogen Receptor-Positive and -Negative Cancers [J].

Bianchini, Giampaolo ;

Qi, Yuan ;

Alvarez, Ricardo H. ;

Iwamoto, Takayuki ;

Coutant, Charles ;

Ibrahim, Nuhad K. ;

Valero, Vicente ;

Cristofanilli, Massimo ;

Green, Marjorie C. ;

Radvanyi, Laszlo ;

Hatzis, Christos ;

Hortobagyi, Gabriel N. ;

Andre, Fabrice ;

Gianni, Luca ;

Symmans, W. Fraser ;

Pusztai, Lajos .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (28) :4316-4323

[7] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[8] HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C [J].

Braud, VM ;

Allan, DSJ ;

O'Callaghan, CA ;

Söderström, K ;

D'Andrea, A ;

Ogg, GS ;

Lazetic, S ;

Young, NT ;

Bell, JI ;

Phillips, JH ;

Lanier, LL ;

McMichael, AJ .

NATURE, 1998, 391 (6669) :795-799

[9] Human natural killer cells [J].

Caligiuri, Michael A. .

BLOOD, 2008, 112 (03) :461-469

[10] HLA class I antigen loss, tumor immune escape and immune selection [J].

Campoli, M ;

Chang, CC ;

Ferrone, S .

VACCINE, 2002, 20 :A40-A45

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