Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

被引：560

作者：

Keizer, R. J. ^{[1
]}

Karlsson, M. O. ^{[1
]}

Hooker, A. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Pharmaceut Biosci, Pharmacometr Res Grp, Uppsala, Sweden

来源：

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2013年 / 2卷 / 06期

关键词：

D O I：

10.1038/psp.2013.24

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tutorial, we provide some guidance on what diagnostics we consider most useful in pharmacokinetic model development and how to construct them using these tools.

引用

页数：9

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