Oxybutynin for the Treatment of Primary Hyperhidrosis: Current State of the Art

被引:22
作者
Campanati, Anna [1 ]
Gregoriou, Stamatis [3 ]
Kontochristopoulos, George [2 ]
Offidani, Annamaria [1 ]
机构
[1] Polytech Univ Marche, Dept Clin & Mol Sci, Dermatol Unit, Ancona, Italy
[2] Andreas Sygros Hosp, Hyperhidrosis Clin, Athens, Greece
[3] Univ Athens, Attikon Hosp, Med Sch, Dept Dermatol & Venereol 2, 1 Rimini Str, GR-12642 Athens, Greece
关键词
Botulinum toxin; Children; Hyperhidrosis; Sweat glands; Xerostomia;
D O I
10.1159/000371581
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Oxybutynin is an anticholinergic drug with an emerging role in the treatment of hyperhidrosis. Several recent studies have documented that it is effective both in focal and generalized hyperhidrosis and shows universally good response among different groups of patients regardless of age, gender, and weight. The most common adverse event is dry mouth reported by almost all patients treated. The way this might affect long-term compliance and tolerability should be better investigated in the future. (C) 2015 S. Karger AG, Basel
引用
收藏
页码:6 / 13
页数:8
相关论文
共 39 条
[1]  
Amir M, 2000, ISRAEL J PSYCHIAT, V37, P25
[2]   Hyperhidrosis: A review of current management [J].
Atkins, JL ;
Butler, PEM .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2002, 110 (01) :222-228
[3]   Prevalence and Disease Burden of Hyperhidrosis in the Adult Population [J].
Augustin, M. ;
Radtke, M. A. ;
Herberger, K. ;
Kornek, T. ;
Heigel, H. ;
Schaefer, I. .
DERMATOLOGY, 2013, 227 (01) :10-13
[4]   Diagnosis and management of hyperhidrosis [J].
Benson, R. A. ;
Palin, R. ;
Holt, P. J. E. ;
Loftus, I. M. .
BMJ-BRITISH MEDICAL JOURNAL, 2013, 347
[5]  
Costa AS, 2014, CLINICS, V69, P101
[6]   Expression of Acetylcholine and Its Receptor in Human Sympathetic Ganglia in Primary Hyperhidrosis [J].
de Moura Junior, Nabor B. ;
das-Neves-Pereira, Joao C. ;
de Oliveira, Flavio R. G. ;
Jatene, Fabio B. ;
Parra, Edwin R. ;
Capelozzi, Vera L. ;
Wolosker, Nelson ;
de Campos, Jose R. M. .
ANNALS OF THORACIC SURGERY, 2013, 95 (02) :465-471
[7]   Epidemiological study and considerations of primary focal hyperhidrosis in Japan: From questionnaire analysis [J].
Fujimoto, Tomoko ;
Kawahara, Kazuo ;
Yokozeki, Hiroo .
JOURNAL OF DERMATOLOGY, 2013, 40 (11) :886-890
[8]  
Holzle E, 2002, CURR PROBL DERMATOL, V30, P30
[9]   STRUCTURAL-CHANGES IN AXILLARY ECCRINE GLANDS FOLLOWING LONG-TERM TREATMENT WITH ALUMINUM-CHLORIDE HEXAHYDRATE SOLUTION [J].
HOLZLE, E ;
BRAUNFALCO, O .
BRITISH JOURNAL OF DERMATOLOGY, 1984, 110 (04) :399-403
[10]   MEASUREMENT OF OXYBUTYNIN AND ITS N-DESETHYL METABOLITE IN PLASMA, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN YOUNG, ELDERLY AND FRAIL ELDERLY VOLUNTEERS [J].
HUGHES, KM ;
LANG, JCT ;
LAZARE, R ;
GORDON, D ;
STANTON, SL ;
MALONELEE, J ;
GERAINT, M .
XENOBIOTICA, 1992, 22 (07) :859-869