Peculiarities of vascular control over platelet aggregation in patients with Arterial hypertension of the 3rd degree at metabolic syndrome

In spite of the fact that the great practical signification of evidence of vessels' antiaggregatory control over platelets' activity in patients with metabolic syndrome and arterial hypertension of the 3rd degree, given question can't be considered fully studied. The aim is to ascertain the evidence of vascular wall's antiaggregatory dysfunction at arterial hypertension of the 3rd degree with accompanying metabolic syndrome. We observed 47 patients of middle age with arterial hypertension of the 3rd degree at metabolic syndrome. Control group was composed of 25 healthy people of the same age. We used biochemical, hematological and statistical methods of investigation. Examined patients had an evident strengthening of platelets' aggregatory function and lowering of vascular wall's antiaggregatory ability. These abnormalities were accompanied by deep shears in lipidic metabolism, activation of plasma lipids' peroxidation, weakening of nitric oxide synthesis in the vascular wall, output misbalance of arachidonic acid metabolites in vessels and platelets and strengthening of von Willebrand Factor synthesis in thevascular wall. Patients with arterial hypertension of the 3rd degree at metabolic syndrome on the background of platelets' intense aggregatory activity had anevident lowering of vascular wall's antiaggregatory ability. Given abnormalities surpasses the same ones at arterial hypertension of the 1st and 2nd degree at metabolic syndrome. They are important factors in the rise of thrombogenic danger for examined category of patients.