The role of the NLRP3 inflammasome in gout

被引：185

作者：

Kingsbury, Sarah R. ^{[1
,2
]}

Conaghan, Philip G. ^{[1
,2
]}

McDermott, Michael F. ^{[1
,2
]}

机构：

[1] Leeds Inst Mol Med, Sect Musculoskeletal Dis, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

[2] Univ Leeds, Leeds Inst Mol Med, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2011年 / 4卷

关键词：

gout; inflammasome; NLRP3; IL-1;

D O I：

10.2147/JIR.S11330

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Recent studies suggest that orchestration of the MSU-induced inflammatory response is dependent on the proinflammatory cytokine IL-1 beta, underlined by promising results in early IL-1 inhibitor trials in gout patients. This IL-1-dependent innate inflammatory phenotype, which is observed in a number of diseases in addition to gout, is now understood to rely on the formation of the macromolecular NLRP3 inflammasome complex in response to the MSU 'danger signal'. This review focuses on our current understanding of the NLRP3 inflammasome and its critical role in MSU-crystal induced inflammatory gout attacks. It also discusses the management of treatment-resistant acute and chronic tophaceous gout with IL-1 inhibitors; early clinical studies of rilonacept (IL-1 Trap), canakinumab (monoclonal anti-IL-1 beta antibody), and anakinra have all demonstrated treatment efficacy in such patients.

引用

页码：39 / 49

页数：11

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