SYNTHESIS OF PHENYL HYDRAZINE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

被引：13

作者：

Venkataramana, H. S. C. ^{[1
]}

Singh, A. ^{[2
]}

Tiwari, A. ^{[1
]}

Tiwari, V ^{[1
]}

机构：

[1] MS Ramaiah Coll Pharm, Dept Pharmaceut Chem, Bangalore, Karnataka, India

[2] Devsthali Vidyapeeth Coll Pharm, Rudrapur, Uttrakhand, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2010年 / 1卷 / 01期

关键词：

2-chloromethyl benzimidazole; phenyl hydrazine; antimicrobial activity;

D O I：

10.13040/IJPSR.0975-8232.1(1).34-38

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN' disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and Invitro anti-inflammatory activity.

引用

页数：5

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