Resolution of Left Ventricular Thrombus Secondary to Tachycardia-Induced Heart Failure with Rivaroxaban

被引：18

作者：

Nakasuka, Kosuke ^{[1
]}

Ito, Shigenori ^{[1
]}

Noda, Tsubasa ^{[1
]}

Hasuo, Takahiro ^{[1
]}

Sekimoto, Satoru ^{[1
]}

Ohmori, Hiroyuki ^{[1
]}

Inomata, Masahiko ^{[1
]}

Yoshida, Takayuki ^{[1
]}

Tamai, Nozomu ^{[1
]}

Saeki, Tomoaki ^{[1
]}

Suzuki, Shin ^{[1
]}

Murakami, Yoshimasa ^{[1
]}

Sato, Koichi ^{[1
]}

机构：

[1] Nagoya City East Med Ctr, Div Cardiol, Chikusa Ku, 1-2-23Wakamizu, Nagoya, Aichi 4648547, Japan

来源：

CASE REPORTS IN MEDICINE | 2014年 / 2014卷

关键词：

D O I：

10.1155/2014/814524

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 42-year-old man was admitted to our hospital because of lumbago and tachycardia-induced heart failure. Transthoracic echocardiography revealed impaired left ventricular function and a ball mass of thrombus in the left ventricle (LV). He was found to have systemic embolism in the spleen, kidneys, brain, and limbs. The patient was treated with limb thrombectomy followed by anticoagulation. Seven days after the direct factor Xa inhibitor, rivaroxaban, was initiated, transthoracic echocardiography was repeated, revealing disappearance of the LV thrombus without any clinical signs of cardiogenic embolism. His heart failure responded well and the LV wall motion had improved. This case suggests rivaroxaban has fibrinolytic effects on thrombi even in the LV.

引用

页数：5

共 15 条

[1] Dabigatran versus Warfarin in Patients with Atrial Fibrillation. [J].

Connolly, Stuart J. ;

Ezekowitz, Michael D. ;

Yusuf, Salim ;

Eikelboom, John ;

Oldgren, Jonas ;

Parekh, Amit ;

Pogue, Janice ;

Reilly, Paul A. ;

Themeles, Ellison ;

Varrone, Jeanne ;

Wang, Susan ;

Alings, Marco ;

Xavier, Denis ;

Zhu, Jun ;

Diaz, Rafael ;

Lewis, Basil S. ;

Darius, Harald ;

Diener, Hans-Christoph ;

Joyner, Campbell D. ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) :1139-1151

[2] The direct factor Xa inhibitor Rivaroxaban reduces platelet activation in congestive heart failure [J].

Flierl, Ulrike ;

Fraccarollo, Daniela ;

Micka, Jan ;

Bauersachs, Johann ;

Schaefer, Andreas .

PHARMACOLOGICAL RESEARCH, 2013, 74 :49-55

[3] 2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines 2006 WRITING COMMITTEE MEMBERS Developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society [J].

Fuster, Valentin ;

Ryden, Lars E. ;

Cannom, Davis S. ;

Crijns, Harry J. ;

Curtis, Anne B. ;

Ellenbogen, Kenneth A. ;

Halperin, Jonathan L. ;

Kay, G. Neal ;

Le Huezey, Jean-Yves ;

Lowe, James E. ;

Olsson, S. Bertil ;

Prystowsky, Eric N. ;

Tamargo, Juan Luis ;

Wann, L. Samuel ;

Estes, N. A. Mark, III ;

Ezekowitz, Michael D. ;

Jackman, Warren M. ;

January, Craig T. ;

Page, Richard L. ;

Slotwiner, David J. ;

Stevenson, William G. ;

Tracy, Cynthia M. ;

Jacobs, Alice K. ;

Anderson, Jeffrey L. ;

Albert, Nancy ;

Buller, Christopher E. ;

Creager, Mark A. ;

Ettinger, Steven M. ;

Guyton, Robert A. ;

Hochman, Judith S. ;

Kushner, Frederick G. ;

Ohman, Erik Magnus ;

Tarkington, Lynn G. ;

Yancy, Clyde W. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (11) :E101-E198

[4] Apixaban versus Warfarin in Patients with Atrial Fibrillation [J].

Granger, Christopher B. ;

Alexander, John H. ;

McMurray, John J. V. ;

Lopes, Renato D. ;

Hylek, Elaine M. ;

Hanna, Michael ;

Al-Khalidi, Hussein R. ;

Ansell, Jack ;

Atar, Dan ;

Avezum, Alvaro ;

Cecilia Bahit, M. ;

Diaz, Rafael ;

Easton, J. Donald ;

Ezekowitz, Justin A. ;

Flaker, Greg ;

Garcia, David ;

Geraldes, Margarida ;

Gersh, Bernard J. ;

Golitsyn, Sergey ;

Goto, Shinya ;

Hermosillo, Antonio G. ;

Hohnloser, Stefan H. ;

Horowitz, John ;

Mohan, Puneet ;

Jansky, Petr ;

Lewis, Basil S. ;

Luis Lopez-Sendon, Jose ;

Pais, Prem ;

Parkhomenko, Alexander ;

Verheugt, Freek W. A. ;

Zhu, Jun ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (11) :981-992

[5] Resolution of giant left atrial appendage thrombus with rivaroxaban [J].

Hammerstingl, Christoph ;

Poetzsch, Berndt ;

Nickenig, Georg .

THROMBOSIS AND HAEMOSTASIS, 2013, 109 (04) :583-584

[6] Resolution of left atrial appendage thrombus with apixaban [J].

Kawakami T. ;

Kobayakawa H. ;

Ohno H. ;

Tanaka N. ;

Ishihara H. .

Thrombosis Journal, 11 (1)

[7] Resolution of a left ventricular thrombus by the thrombolytic action of dabigatran [J].

Nagamoto, Yasutsugu ;

Shiomi, Tetsuya ;

Matsuura, Taku ;

Okahara, Arihide ;

Takegami, Kaoru ;

Mine, Daigo ;

Shirahama, Takaharu ;

Koga, Yasuaki ;

Yoshida, Keiki ;

Sadamatsu, Kenji ;

Hayashida, Kiyoshi .

HEART AND VESSELS, 2014, 29 (04) :560-562

[8] Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation [J].

Patel, Manesh R. ;

Mahaffey, Kenneth W. ;

Garg, Jyotsna ;

Pan, Guohua ;

Singer, Daniel E. ;

Hacke, Werner ;

Breithardt, Guenter ;

Halperin, Jonathan L. ;

Hankey, Graeme J. ;

Piccini, Jonathan P. ;

Becker, Richard C. ;

Nessel, Christopher C. ;

Paolini, John F. ;

Berkowitz, Scott D. ;

Fox, Keith A. A. ;

Califf, Robert M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (10) :883-891

[9]

Potu CR, 2012, AUSTRALAS MED J, V5, P178, DOI [10.4066/AMJ.2012.110, 10.4066/AMJ.20121103]

[10] Resolution of ventricular thrombus identified by contrast enhanced cardiac MRI [J].

Selvanayagam, JB ;

Spyrou, N ;

Francis, JM ;

Neubauer, S .

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2004, 20 (05) :369-370

← 1 2 →