HYPERTHERMIC STRESS MODULATES THE FUNCTIONS OF RAT-LIVER GLUCOCORTICOID RECEPTOR

被引：13

作者：

MATIC, G ^{[1
]}

KIPIC, J ^{[1
]}

RISTIC, B ^{[1
]}

DUNDJERSKI, J ^{[1
]}

TRAJKOVIC, D ^{[1
]}

机构：

[1] INST BIOL RES,DEPT ECOL,YU-11060 BELGRADE,YUGOSLAVIA

来源：

CELL BIOLOGY INTERNATIONAL | 1995年 / 19卷 / 03期

关键词：

D O I：

10.1006/cbir.1995.1063

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A mild whole body hyperthermic stress causes a rapid and reversible reduction of rat liver glucocorticoid receptor (GR) binding capacity and affects the stability of the GR-DNA complexes formed after thermal transformation of the receptor. These changes appear to be physiologically relevant, since they are accompanied by a decrease in dexamethasone induction of hepatic tyrosine aminotransferase (TAT). In spite of the decreased rate of the GR degradation in Liver cytosol of hyperthermic as compared to control rats, the total amount of the GR and its proteolytic products recognized by BuGR2 monoclonal antibody was found to be lower in the former cytosol, bur higher in the respective nuclei.

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页码：203 / 213

页数：11

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