THE EPIBATIDINE COMPETITION - SYNTHETIC WORK ON A NOVEL NATURAL ANALGESIC

被引：25

作者：

DEHMLOW, EV

机构：

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1995年 / 337卷 / 03期

关键词：

D O I：

10.1002/prac.19953370139

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Epibatidine was isolated in 1992 from a South American poison frog. It has a unique structure among natural products, and its analgetic activity surpasses that of morphine up to 500 fold. Pharmacological interest in epibatidine focusses also on the fact that its mode of action is different from that of morphine. 10 independent syntheses were published in 1993/1994. They are compared here demonstrating the interaction of classical and modern synthetic methods.

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页码：167 / 174

页数：8

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