NUCLEOLAR ORGANIZER REGIONS (NORS) IN LYMPHOPROLIFERATIVE DISORDERS OF THE HUMAN SALIVARY-GLAND

被引:0
作者
TAKAHASHI, H
FUJITA, S
CHENG, J
TSUDA, N
TEZUKA, F
LIU, AR
OKABE, H
机构
[1] NAGASAKI UNIV HOSP,CENT DIAGNOST LAB,DIV PATHOL,NAGASAKI,JAPAN
[2] SHANGHAI MED UNIV 2,SCH STOMATOL,DEPT ORAL PATHOL,SHANGHAI,PEOPLES R CHINA
[3] TOHOKU UNIV,TB & CANC RES INST,SENDAI,MIYAGI 980,JAPAN
来源
ANALYTICAL CELLULAR PATHOLOGY | 1994年 / 6卷 / 01期
关键词
MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA; MYOEPITHELIAL SIALADENITIS; NUCLEOLAR ORGANIZER REGIONS; SALIVARY GLAND;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The relationship between the silver-stained proteins of the nucleolar organizer regions (AgNORs) and proliferative activity was studied in 30 patients with lymphoproliferative disorders of the major salivary gland. The salivary gland lesions were microscopically and immunohistochemically differentiated into myoepithelial sialadenitis (MESA, n = 6), low-grade B-cell lymphoma (n = 16), high-grade B-cell lymphoma (n = 5), and T-cell lymphoma (n = 3). The mean AgNOR count per nucleus for MESA was 2.48; for low-grade B-cell lymphoma, 2.19; for high-grade B-cell lymphoma, 6.37; and for T-cell lymphoma, 5.46. There was no significant difference in AgNOR counts per nucleus between the MESA and low-grade B-cell lymphoma, whereas the high-grade B-cell lymphomas exhibited significantly increased mean AgNOR number. Furthermore, the mean numbers of AgNOR were compared with cellular types of lymphoproliferative disorders. A statistically significant difference did exist among AgNOR counts of centroblasts, centrocytes and mantle zone lymphocytes or interfollicular lymphocytes in MESA. There was no significant difference in AgNOR counts per nucleus among the centroblasts of MESA, neoplastic centroblasts of centroblastic/centrocytic lymphoma, and centroblastic lymphoma. It was shown that AgNOR enumeration of tumor cells in mucosa-associated lymphoid tissue (MALT) lymphoma was similar to those seen in mantle zone and interfollicular lymphocytes of MESA. Therefore, we propose that MALT lymphoma may represent a mucosal counterpart of mantle zone lymphocyte- or interfollicular lymphocyte-related low-grade B-cell lymphomas.
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页码:51 / 63
页数:13
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