CHRONIC BARBITURATE TREATMENT INCREASES NMDA RECEPTORS BUT DECREASES KAINATE RECEPTORS IN MOUSE CORTEX

被引：20

作者：

SHORT, KR ^{[1
]}

TABAKOFF, B ^{[1
]}

机构：

[1] UNIV COLORADO, HLTH SCI CTR,SCH MED,DEPT PHARMACOL,4200 E 9TH AVE, DENVER, CO 80262 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 01期

关键词：

PHENOBARBITAL; DEPENDENCE; GLUTAMATE RECEPTORS; BRAIN;

D O I：

10.1016/0014-2999(93)90419-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic phenobarbital effects on brain NMDA and kainate receptors were assessed using [H-3]MK-801 and [H-3]kainate. Mice fed a phenobarbital diet for 7 days had a higher density of MK-801 binding sites (NMDA receptors) but a lower density of kainate receptors in cortex than control mice. No changes in MK-801 or kainate binding were observed in hippocampus. The results suggest brain area specific adaptation of certain glutamate receptors to chronic barbiturate treatment.

引用

页码：111 / 114

页数：4

共 14 条

[11] THE RELATIVE POTENCY OF PENTOBARBITAL IN SUPPRESSING THE KAINIC ACID-INDUCED OR THE N-METHYL-D-ASPARTIC ACID-INDUCED ENHANCEMENT OF CGMP IN CEREBELLAR CELLS [J].

MORGAN, WW ;

BERMUDEZ, J ;

CHANG, XY .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 204 (03) :335-338

[12] SELECTIVE EFFECTS OF SEDATIVE HYPNOTIC DRUGS ON EXCITATORY AMINO-ACID RECEPTORS IN BRAIN [J].

TABAKOFF, B ;

RABE, CS ;

HOFFMAN, PL .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 625 :488-495

[13] BRAIN NORADRENERGIC SYSTEMS AS A PREREQUISITE FOR DEVELOPING TOLERANCE TO BARBITURATES [J].

TABAKOFF, B ;

YANAI, J ;

RITZMANN, RF .

SCIENCE, 1978, 200 (4340) :449-451

[14] ALCOHOL AND ANESTHETIC ACTIONS ON EXCITATORY AMINO ACID-ACTIVATED ION CHANNELS [J].

WEIGHT, FF ;

LOVINGER, DM ;

WHITE, G ;

PEOPLES, RW .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 625 :97-107

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