CHRONIC BARBITURATE TREATMENT INCREASES NMDA RECEPTORS BUT DECREASES KAINATE RECEPTORS IN MOUSE CORTEX

被引：20

作者：

SHORT, KR ^{[1
]}

TABAKOFF, B ^{[1
]}

机构：

[1] UNIV COLORADO, HLTH SCI CTR,SCH MED,DEPT PHARMACOL,4200 E 9TH AVE, DENVER, CO 80262 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 01期

关键词：

PHENOBARBITAL; DEPENDENCE; GLUTAMATE RECEPTORS; BRAIN;

D O I：

10.1016/0014-2999(93)90419-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic phenobarbital effects on brain NMDA and kainate receptors were assessed using [H-3]MK-801 and [H-3]kainate. Mice fed a phenobarbital diet for 7 days had a higher density of MK-801 binding sites (NMDA receptors) but a lower density of kainate receptors in cortex than control mice. No changes in MK-801 or kainate binding were observed in hippocampus. The results suggest brain area specific adaptation of certain glutamate receptors to chronic barbiturate treatment.

引用

页码：111 / 114

页数：4

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