BASIC FIBROBLAST GROWTH-FACTOR PROMOTES INVIVO CEREBRAL ANGIOGENESIS IN CHRONIC FOREBRAIN ISCHEMIA

被引：69
作者：
LYONS, MK
ANDERSON, RE
MEYER, FB
机构：
[1] MAYO CLIN & MAYO FDN,DEPT NEUROL SURG,CEREBRAL VASC RES LAB,ROCHESTER,MN 55905
[2] MAYO CLIN & MAYO GRAD SCH MED,ROCHESTER,MN 55901
来源：
BRAIN RESEARCH | 1991年 / 558卷 / 02期
关键词：
BASIC FIBROBLAST GROWTH FACTOR; ANGIOGENESIS; RAT; ISCHEMIA; CAPILLARY;
D O I：
10.1016/0006-8993(91)90784-S
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.
引用
收藏
页码：315 / 320
页数：6
相关论文
共 27 条
[1]   MIGRATION AND PROLIFERATION OF ENDOTHELIAL CELLS IN PREFORMED AND NEWLY FORMED BLOOD-VESSELS DURING TUMOR ANGIOGENESIS [J].
AUSPRUNK, DH ;
FOLKMAN, J .
MICROVASCULAR RESEARCH, 1977, 14 (01) :53-65
[2]  
BROWN AW, 1968, BRIT J EXP PATHOL, V49, P87
[3]   THE ARCHITECTURE OF THE CEREBRAL CAPILLARY BED [J].
CRAIGIE, EH .
BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY, 1945, 20 (04) :133-146
[4]  
DEJUAN E, 1990, INVEST OPHTH VIS SCI, V31, P1238
[5]  
FOLKMAN J, 1988, AM J PATHOL, V130, P393
[6]   TUMOR-GROWTH AND NEOVASCULARIZATION - EXPERIMENTAL MODEL USING RABBIT CORNEA [J].
GIMBRONE, MA ;
COTRAN, RS ;
LEAPMAN, SB ;
FOLKMAN, J .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 52 (02) :413-427
[7]   STRUCTURAL CHARACTERIZATION AND BIOLOGICAL FUNCTIONS OF FIBROBLAST GROWTH-FACTOR [J].
GOSPODAROWICZ, D ;
FERRARA, N ;
SCHWEIGERER, L ;
NEUFELD, G .
ENDOCRINE REVIEWS, 1987, 8 (02) :95-114
[8]   ANGIOGENIC ACTIVITY OF THE FIBROBLAST AND EPIDERMAL GROWTH-FACTOR [J].
GOSPODAROWICZ, D ;
BIALECKI, H ;
THAKRAL, TK .
EXPERIMENTAL EYE RESEARCH, 1979, 28 (05) :501-514
[9]   HEPARIN PROTECTS BASIC AND ACIDIC FGF FROM INACTIVATION [J].
GOSPODAROWICZ, D ;
CHENG, J .
JOURNAL OF CELLULAR PHYSIOLOGY, 1986, 128 (03) :475-484
[10]   THE ROLE OF FIBROBLAST GROWTH-FACTOR AND THE EXTRACELLULAR-MATRIX IN THE CONTROL OF PROLIFERATION AND DIFFERENTIATION OF CORNEAL ENDOTHELIAL-CELLS [J].
GOSPODAROWICZ, D ;
VLODAVSKY, I ;
SAVION, N .
VISION RESEARCH, 1981, 21 (01) :87-103
123