RENAL EFFECTS OF GROWTH-HORMONE .2. ELECTROLYTE HOMEOSTASIS AND BODY-COMPOSITION

被引：32
作者：
OGLE, GD [1 ]
ROSENBERG, AR [1 ]
KAINER, G [1 ]
机构：
[1] PRINCE WALES CHILDRENS HOSP,DEPT NEPHROL,HIGH ST,SYDNEY,NSW 2031,AUSTRALIA
来源：
PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 05期
关键词：
GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; CALCIUM HOMEOSTASIS; BODY COMPOSITION;
D O I：
10.1007/BF00874021
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Growth hormone (GH), either directly or through insulin-like growth factor-1 (IGF-1), has a wide spectrum of physiological and renal effects. This review concentrates on the effects of GH (derived from either pituitary or recombinant technology) and IGF-1 in three main areas: (1) sodium and water homeostasis; (2) calcium and phosphate balance, bone density and interactions with mineral regulating hormones; (3) fat and lean body mass. Observations of physiological changes in states of GH deficiency and excess in humans and animal models are presented. The lack of long-term toxicological data indicates that GH treatment for short stature in non-GH deficient children, with or without renal disease, should proceed with caution.
引用
收藏
页码：483 / 489
页数：7
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