INHIBITION OF PIGEON BREAST MUSCLE ALPHA-KETOGLUTARATE DEHYDROGENASE BY PHOSPHONATE ANALOGS OF ALPHA-KETOGLUTARATE

被引：25
|
作者：
BUNIK, VI [1 ]
BIRYUKOV, AI [1 ]
ZHUKOV, YN [1 ]
机构：
[1] ACAD SCI USSR,INST MOLEC BIOL,MOSCOW 117984,USSR
来源：
FEBS LETTERS | 1992年 / 303卷 / 2-3期
关键词：
ALPHA-KETOGLUTARATE DEHYDROGENASE; TRANSITION STATE ANALOG; SUCCINYLPHOSPHONATE; SLOW ISOMERIZATION;
D O I：
10.1016/0014-5793(92)80518-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. Alpha-ketoglutarate binds to the enzyme-inhibitor complex, preventing its isomerisation.
引用
收藏
页码：197 / 201
页数：5
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